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KMID : 0356920070530010097
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Korean Journal of Anesthesiology
2007 Volume.53 No. 1 p.97 ~ p.103
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The Effect of Minocycline on Allodynia Produced by Repeated Injection of Low pH Saline in Rats
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Kang Hyun
Woo Young-Cheol
Baek Chong-Wha
Jung Yong-Hun
Kim Jin-Yun
Koo Gill-Hoi
Park Sun-Gyoo
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Abstract
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Backgrond: Activation of glial cells (microglia and astroglia) has been observed in rat neuropathic pain models and they are known to play a role in inducing allodynia in these animals. Minocycline (MC), a tetracycline derivative antibiotics, displays selective inhibition of microglial activation. The author investigated antinociceptive effect of intrathecal administration of MC on muscular pain model induced by repetitive intramuscular injection of low pH saline.
Methods: pH 5 saline was injected into gastrocnemius muscle of rat. Second injection of pH 5 saline was done 3 days after first injection. To study preventive effect of MC, normal saline or MC 50?g or 100?g was administered intrathecally 15 min before each low pH saline injection. To evaluate the therapeutic effect, normal saline or MC 500?g was administered intrathecally after pain model made. To quantify the mechanical allodynia, withdrawal threshold to mechanical stimuli was measured using von Frey filament.
Results: Preventive administration of MC 50?g did not attenuate the mechanical allodynia, on the contrary MC 100?g administration showed pain attenuation. Therapeutic administration of MC 500?g did not show analgesic effect.
Conclusions: Preventive intrathecal administration of MC 100?g attenuated mechanical allodynia, but not in preventive MC 50?g and therapeutic administration. (Korean J Anesthesiol 2007; 53: 97∼103)
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KEYWORD
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acid, allodynia, microglia, minocycline, muscle injection.
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